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If found to be correlated with suscepti-bility, exposure, and effect, these biomarkers could consid-erably alter conventional approaches to risk assessment.Perhaps the best known example of such a correlation isurinary aflatoxin–DnA adducts and liver cancer. Metal fume fever is thought to be an immuneresponse characterized by flu-like symptoms and impairedlung function. These substances are re-sponsible for the severe vascular disturbances associated withhypersensitivity reactions and anaphylaxis. Cargo receptors recognize andbind to specific molecules that come in contact with theplasma membrane. She also complains of excessive menstrual bleeding for the last 3 months, althoughit was normal previously

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